Structure of PDB 5wri Chain A Binding Site BS01

Receptor Information
>5wri Chain A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQMW
SRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFAL
KSLTYLSRLFPNAKFLLMVRDGRASVHSMISRKVTIAGFDLNSYRDCLTK
WNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNHS
VLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQDM
AVIAPMLAKLGYDPYANPPNYGKP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5wri Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		P78 E100 R102 R106 P161 F162 K165 V198 T199 I200 A201 F203 A218 R285
Binding residue
(residue number reindexed from 1)		P14 E36 R38 R42 P97 F98 K101 V134 T135 I136 A137 F139 A154 R221
Enzymatic activity
Enzyme Commision number 2.8.2.20: protein-tyrosine sulfotransferase.
Gene Ontology
Molecular Function
GO:0008476 protein-tyrosine sulfotransferase activity
Biological Process
GO:0006478 peptidyl-tyrosine sulfation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5wri, PDBe:5wri, PDBj:5wri
PDBsum5wri
PubMed28821720
UniProtO60507|TPST1_HUMAN Protein-tyrosine sulfotransferase 1 (Gene Name=TPST1)

[Back to BioLiP]