Structure of PDB 5wj8 Chain A Binding Site BS01

Receptor Information
>5wj8 Chain A (length=210) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAK
ALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVL
DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLA
SGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKK
DHILQVTILD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5wj8 Chain A Residue 1601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5wj8 Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Resolution1.86 Å
Binding residue
(original residue number in PDB)		D1370 G1372 K1374 D1376
Binding residue
(residue number reindexed from 1)		D84 G86 K88 D90
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5wj8, PDBe:5wj8, PDBj:5wj8
PDBsum5wj8
PubMed30033219
UniProtQ9H251|CAD23_HUMAN Cadherin-23 (Gene Name=CDH23)

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