Structure of PDB 5wci Chain A Binding Site BS01

Receptor Information
>5wci Chain A (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HSSGLVPRGSTKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYC
LKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVHEVDGKDHKIYCQNL
CLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNN
VACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRS
YWSWVLLENLRDFRGLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHV
ICVTPKLVEEHLKSAQYKPPITVDSVCLKWAPPK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5wci Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5wci Human MYST histone acetyltransferase 1
Resolution1.78 Å
Binding residue
(original residue number in PDB)		C210 C213 H226 C230
Binding residue
(residue number reindexed from 1)		C47 C50 H63 C67
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) C316 E350
Catalytic site (residue number reindexed from 1) C153 E187
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5wci, PDBe:5wci, PDBj:5wci
PDBsum5wci
PubMed
UniProtQ9H7Z6|KAT8_HUMAN Histone acetyltransferase KAT8 (Gene Name=KAT8)

[Back to BioLiP]