Structure of PDB 5w8f Chain A Binding Site BS01

Receptor Information
>5w8f Chain A (length=149) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
Ligand information
Receptor-Ligand Complex Structure
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PDB5w8f Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		H224 M231 H252 N260 G262 R263 T266 F318 F319
Binding residue
(residue number reindexed from 1)		H53 M60 H81 N89 G91 R92 T95 F147 F148
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

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Biological Process
External links
PDB RCSB:5w8f, PDBe:5w8f, PDBj:5w8f
PDBsum5w8f
PubMed29339518
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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