Structure of PDB 5w6q Chain A Binding Site BS01

Receptor Information
>5w6q Chain A (length=515) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDL
KEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYG
GEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHVE
ATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLF
DELGLPAIGKTEKTGKRSTSAAVLEALREAHAIVEKILQYRELTKLKSTY
IDPLPELIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIR
RAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASR
AAKTINFGVLYGMSAHRLSQELAIPYIERYFQSFPKVRAWIEKTLEEGRR
RGYVETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMV
KLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVP
LEVEVGIGEDWLSAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5w6q Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		R487 T506 E507 K508 T509 S513 T514 S515 A516 R536 K540 Y545 R573 Q582 N583 I584 P585 R587 H784 D785 E786
Binding residue
(residue number reindexed from 1)		R192 T211 E212 K213 T214 S218 T219 S220 A221 R241 K245 Y250 R278 Q287 N288 I289 P290 R292 H468 D469 E470
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5w6q, PDBe:5w6q, PDBj:5w6q
PDBsum5w6q
PubMed29986111
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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