Structure of PDB 5w21 Chain A Binding Site BS01

Receptor Information
>5w21 Chain A (length=922) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPGDGAQTWARFSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQH
GKGASIWDTFTHHPPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSI
SWARVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQ
DAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATG
RLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSSH
WINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPD
FTESEKKFIKGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWI
DLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGVD
VIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLI
EKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDV
HHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWAL
ILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLL
ARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGH
NLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFSQKDKEVAER
VLEFDIGWLAEPIFGSGDYPWVMRDWLNQRNNFLLPYFTEDEKKLIQGTF
DFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLNSPSQVAVVPWG
LRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKA
HILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSN
GFPGPRFCPEEFTVCTECSFFH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5w21 Chain A Residue 1008 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5w21 alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D426 C739 D745 D815
Binding residue
(residue number reindexed from 1)		D375 C688 D694 D764
Annotation score1
Enzymatic activity
Enzyme Commision number 3.2.1.31: beta-glucuronidase.
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5w21, PDBe:5w21, PDBj:5w21
PDBsum5w21
PubMed29342138
UniProtQ9UEF7|KLOT_HUMAN Klotho (Gene Name=KL)

[Back to BioLiP]