Structure of PDB 5w1i Chain A Binding Site BS01 |
| >5w1i Chain A (length=1294) Species: 1898203 (Lachnospiraceae bacterium)
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KLTVNAKTAVVSENRSQEGILYNDPSRYGKSRKNDEDRDRYIESRLKSSG
KLYRIFNEDELQWFLSEIVKKINRRNGLVLSDMLSVDDRAFEKAFEKYAE
LSYTNRRNKVSGSPAFETCGVDAATAERLKGIISETNFINRIKNNIDNKV
SEDIIDRIIAKYLKKSLCRERVKRGLKKLLMNAFDLPYSDPDIDVQRDFI
DYVLEDFYHVRAKSQVSRSIKNMNMPVQPEGDGKFAITVSKGGTESGNKR
SAEKEAFKKFLSDYASLDERVRDDMLRRMRRLVVLYFYGSDDSKLSDVNE
KFDVWEDHAARRVDNREFIKLPLENTDKDAERIRKNTVKELYRNQNIGCY
RQAVKAVEEDNNGRYFDDKMLNMFFIHRIEYGVEKIYANLKQVTEFKART
GYLSEKIWKDLINYISIKYIAMGKAVYNYAMDELNASDKKEIELGKISEE
YLSGISSFDYELIKAEEMLQRETAVYVAFAARHLSSQTVELDSENSDFLL
LKPKGTMDKNDKNKLASNNILNFLKDKETLRDTILQYFGGHSLWTDFPFD
KYLAGGKDDVDFLTDLKDVIYSMRNDSFHYATNNGKWNKELISAMFEHET
ERMTVVMKDKFYSNNLPMFYKNDDLKKLLIDLYKDNVERASQVPSFNKVF
VRKNFPALVRDKDNLGIELDLDKGENELKFYNALYYMFKEIYYNAFLNDK
NVRERFITKATKVADNNYIAENDFGQRIKNIVQVNPDYTLAQICQLIMTE
YNCMQKKSAHYKMLLLVNLRKAFLEFIKENYAFVLKPYKHDLCDKADFVP
DFAKYVKPYAGLISRVAGSSELQKWYIVSRFLSPAQANHMLGFLHSYKQY
VWDIYRRASETGTEINHSIAEDKIAGVDITDVDAVIDLSVKLCGTISSEI
SDYFKDDEVYAEYISSYLDFEYDGGNYKDSLNRFCNSDAVNDQKVALYYD
GEHPKLNRNIILSKLYGERRFLEKITDRVSRSDIVEYYKLKKETSQYQTK
GIFDSEDEQKNIKKFQEMKNIVEFRDLMDYSEIADELQGQLINWIYLRER
DLMNFQLGYHYACLNNDSNKQATYVTLDYQGKKNRKINGAILYQICAMYI
NGLPLYYVDKDSSEWTVSDGKESTGAKIGEFYRYAKSFSDCYASGLEIFE
NISEHDNITELRNYIEHFRYYSSFDRSFLGIYSEVFDRFFTYDLKYRKNV
PTILYNILLQHFVNVRFEFVSGKKMIGIDKKIAKEKECARITIREKNGVY
SEQFTYKLKNGTVYVDARDKRYLQSIIRLLFYPEKVNMDEMIEV |
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| PDB | 5w1i Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme. |
| Resolution | 2.2 Å |
Binding residue
(original residue number in PDB) | K14 L15 T16 T21 R127 R189 R231 R238 S239 N242 M243 M245 S260 T264 S266 R270 R369 I373 Y376 R377 H403 E406 Y407 E410 K411 K417 F422 K423 K432 Y440 I443 K444 K450 S483 Y486 E487 K490 K639 S642 N643 R668 Q671 S674 N676 K677 V680 L711 N715 K722 Y726 N814 C820 M821 K823 K840 N916 Y928 D931 V968 G972 R1036 Q1076 F1093 Q1094 K1097 R1128 F1267 D1268 K1276 Y1277 K1279 N1280 P1282 I1284 N1287 F1293 F1300 S1302 K1320 E1321 C1322 A1323 F1338 T1339 Y1340 K1341 |
Binding residue
(residue number reindexed from 1) | K1 L2 T3 T8 R107 R169 R211 R218 S219 N222 M223 M225 S240 T244 S246 R250 R343 I347 Y350 R351 H377 E380 Y381 E384 K385 K391 F396 K397 K406 Y414 I417 K418 K424 S457 Y460 E461 K464 K610 S613 N614 R639 Q642 S645 N647 K648 V651 L678 N682 K689 Y693 N752 C753 M754 K756 K762 N838 Y850 D853 V890 G894 R958 Q998 F1015 Q1016 K1019 R1050 F1186 D1187 K1195 Y1196 K1198 N1199 P1201 I1203 N1206 F1212 F1219 S1221 K1236 E1237 C1238 A1239 F1254 T1255 Y1256 K1257 |
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