Structure of PDB 5w0m Chain A Binding Site BS01

Receptor Information
>5w0m Chain A (length=372) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQD
FPGTKLSLFGSSKNGFGFKQSDLAVCMTINGLETAEGLDCVRTIEELARV
LRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSA
YSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNP
PVIPVLQEIYPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQLWLGL
LRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNHNLGAG
LSRKMTNFIMKAFINGRRVFGIPVKGFPKDYPSKMEYFFDPDVLTEGELA
PNDRCCRICGKIGHFMKDCPMR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5w0m Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Resolution2.298 Å
Binding residue
(original residue number in PDB)		F1045 G1046 I1099 A1102 K1103 V1104 N1124 N1130 S1164 Y1171 L1288 A1290 R1345 I1353 G1354
Binding residue
(residue number reindexed from 1)		F59 G60 I113 A116 K117 V118 N138 N144 S178 Y185 L297 A299 R354 I362 G363
Enzymatic activity
Enzyme Commision number 2.7.7.52: RNA uridylyltransferase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5w0m, PDBe:5w0m, PDBj:5w0m
PDBsum5w0m
PubMed28671666
UniProtQ5VYS8|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)

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