Structure of PDB 5w0b Chain A Binding Site BS01

Receptor Information
>5w0b Chain A (length=334) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQ
DFPGTKLSLFGSSKNGFGFKQSDLAVCMTINGLETAEGLDCVRTIEELAR
VLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLS
AYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRN
PPVIPVLQEICGKNTESVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTT
IVIEDPFDLNHNLGAGLSRKMTNFIMKAFINGRRVFGIPGFPKDYPSKME
YFFDPDVLTEGELAPNDRCCRICGKIGHFMKDCP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5w0b Chain A Residue 1401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5w0b Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Resolution2.614 Å
Binding residue
(original residue number in PDB)		C1347 C1350 H1355 C1360
Binding residue
(residue number reindexed from 1)		C320 C323 H328 C333
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.52: RNA uridylyltransferase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5w0b, PDBe:5w0b, PDBj:5w0b
PDBsum5w0b
PubMed28671666
UniProtQ5VYS8|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)

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