Structure of PDB 5vx3 Chain A Binding Site BS01

Receptor Information
>5vx3 Chain A (length=140) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSQSNRELVVDFLSYKLSQKGYSWSQMAAVKQALREAGDEFELRYRRAFS
DLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVD
KEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
Ligand information
>5vx3 Chain B (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MRPEIRIAQELRRIGDEFNAT
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5vx3 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Resolution1.945 Å
Binding residue
(original residue number in PDB)		Y101 A104 F105 L108 L112 S122 Q125 V126 E129 L130 N136 G138 R139 Y195
Binding residue
(residue number reindexed from 1)		Y45 A48 F49 L52 L56 S66 Q69 V70 E73 L74 N80 G82 R83 Y139
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5vx3, PDBe:5vx3, PDBj:5vx3
PDBsum5vx3
PubMed29149594
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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