Structure of PDB 5vsm Chain A Binding Site BS01

Receptor Information
>5vsm Chain A (length=258) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKQAGLEKINF
SGGEPFLQDRGEYLGKLVRFCKEELALPSVSIVSNGSLIRERWFKDYGEY
LDILAISCDSFDEQVNALIGRGQGKKNHVENLQKLRRWCRDYKVAFKINS
VINRFNVDEDMNEHIKALSPVRWKVFQCLLIEGENSGEDALREAERFLIS
NEEFETFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCTDPSKSILD
VGVEEAIK
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain5vsm Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5vsm Structural studies of viperin, an antiviral radical SAM enzyme.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		C84 Y86 C88 C91 G126 N158 R194
Binding residue
(residue number reindexed from 1)		C11 Y13 C15 C18 G53 N85 R121
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) C84 C88 C91
Catalytic site (residue number reindexed from 1) C11 C15 C18
Enzyme Commision number 4.2.-.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0051607 defense response to virus
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vsm, PDBe:5vsm, PDBj:5vsm
PDBsum5vsm
PubMed28607080
UniProtQ8CBB9|RSAD2_MOUSE S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (Gene Name=Rsad2)

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