Structure of PDB 5vlp Chain A Binding Site BS01

Receptor Information
>5vlp Chain A (length=577) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTK
ILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQGSLVEVYL
LDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVV
SGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPGPLVV
LLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVIT
VGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGT
SQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRV
LTPNLVAALPPWQLFCRTVWSAHSGPTRMATAIARCAPDEELLSCSSFSR
SGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPP
AEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGH
REASIHASCCHAPGLECKVKEHGIPAPEQVTVACEEGWTLTGCSALPSHV
LGAYAVDNTCVVRSRAVTAVAICCRSR
Ligand information
>5vlp Chain Z (length=16) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MESFPGWNLVRIGLLR
Receptor-Ligand Complex Structure
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PDB5vlp Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		V241 N340 A341 Q342 D343 P364 E366 D367 H391 L444
Binding residue
(residue number reindexed from 1)		V157 N255 A256 Q257 D258 P279 E281 D282 H306 L359
Enzymatic activity
Catalytic site (original residue number in PDB) D186 H226 N317 S386
Catalytic site (residue number reindexed from 1) D102 H142 N232 S301
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5vlp, PDBe:5vlp, PDBj:5vlp
PDBsum5vlp
PubMed28825733
UniProtQ8NBP7|PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (Gene Name=PCSK9)

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