Structure of PDB 5vla Chain A Binding Site BS01

Receptor Information
>5vla Chain A (length=352) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTK
ILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSLVEVYLL
DTSIQSDHREIEGRVMVTDFENVPEEDKCDSHGTHLAGVVSGRDAGVAKG
ASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYS
RVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQ
PVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAG
IAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAAL
PP
Ligand information
>5vla Chain Z (length=24) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
TVFTSWEEYLDWVMPWNLVRIGLL
Receptor-Ligand Complex Structure
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PDB5vla Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		D238 A239 V241 N340 A341 P364 E366 D367 I368 I369 T377 C378 F379 H391 A443 L444
Binding residue
(residue number reindexed from 1)		D144 A145 V147 N246 A247 P270 E272 D273 I274 I275 T283 C284 F285 H297 A349 L350
Enzymatic activity
Catalytic site (original residue number in PDB) D186 H226 N317 S386
Catalytic site (residue number reindexed from 1) D101 H132 N223 S292
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5vla, PDBe:5vla, PDBj:5vla
PDBsum5vla
PubMed28825733
UniProtQ8NBP7|PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (Gene Name=PCSK9)

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