Structure of PDB 5vie Chain A Binding Site BS01

Receptor Information

>5vie Chain A (length=666) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADA
YSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPE
AIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQL
EKNLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKD
LKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDG
TNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARN
ELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAY
MPHTFFIGDHANMFPHLKKKAVIDFIYDNRIVLNGIDLKAFLDSLPDVKI
VNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGE
EVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNS
VLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVC
LDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAK
NRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYL
QMWEHYAAGNKPDHMI

Ligand information

>5vie Chain B (length=12) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YPGGSTPVSSAN

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5vie Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	H496 H498 N557 P559 T633 K634 V895
Binding residue (residue number reindexed from 1)	H158 H160 N219 P221 T295 K296 V534

Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

External links

PDB	RCSB:5vie, PDBe:5vie, PDBj:5vie
PDBsum	5vie
PubMed	29058723
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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