Structure of PDB 5vbc Chain A Binding Site BS01

Receptor Information
>5vbc Chain A (length=216) Species: 3988 (Ricinus communis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRLLPFVSSEDPAQRLKQMGTLASALTELQMEFSDDLTYSSGMAPRSANQ
ARFEEGGMQVLTKEDIETLEQCRAMCKRGDCPPLLVVFDSREGFTVEADG
QIKDMTFIAEYTGDVDYIRNREHDDCDSMMTLLLAKDPSKSLVICPDKRG
NIARFISGINNHTLDGKKKQNCKCVRYSVNGECRVFLVATRDIAKGERLY
YDYNGYEHEYPTQHFV
Ligand information
>5vbc Chain C (length=14) Species: 3702 (Arabidopsis thaliana) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KAARKSAPATGGVK
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5vbc Molecular basis for the methylation specificity of ATXR5 for histone H3.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		M216 Q217 D262 M263 Y269 I276 E280 S286 M287 M288 T289 K331 C332 R334 T348 Y361 G363 Y364 E365 E367 Y368
Binding residue
(residue number reindexed from 1)		M58 Q59 D104 M105 Y111 I118 E122 S128 M129 M130 T131 K173 C174 R176 T190 Y203 G205 Y206 E207 E209 Y210
Enzymatic activity
Enzyme Commision number 2.1.1.369: [histone H3]-lysine(27) N-methyltransferase.
External links
PDB RCSB:5vbc, PDBe:5vbc, PDBj:5vbc
PDBsum5vbc
PubMed28383693
UniProtB9RU15|ATXR5_RICCO Probable Histone-lysine N-methyltransferase ATXR5 (Gene Name=ATXR5)

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