Structure of PDB 5vac Chain A Binding Site BS01
Receptor Information
>5vac Chain A (length=215) Species:
3988
(Ricinus communis) [
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RLLPFVSSEDPAQRLKQMGTLASALTELQMEFSDDLTYSSGMAPRSANQA
RFEEGGMQVLTKEDIETLEQCRAMCKRGDCPPLLVVFDSREGFTVEADGQ
IKDMTFIAEYTGDVDYIRNREHDDCDSMMTLLLAKDPSSSLVICPDKRGN
IARFISGINNHTLDGKKKQNCKCVRYSVNGECRVFLVATRDIAKGERLYY
DYNGYEHEYPTQHFV
Ligand information
>5vac Chain C (length=12) Species:
9606
(Homo sapiens) [
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AARKSAPATGGV
Receptor-Ligand Complex Structure
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PDB
5vac
Molecular basis for the methylation specificity of ATXR5 for histone H3.
Resolution
1.949 Å
Binding residue
(original residue number in PDB)
M216 Q217 Y269 S286 M287 M288 T289 C332 R334 Y361 G363 Y364 E365 E367 Y368
Binding residue
(residue number reindexed from 1)
M57 Q58 Y110 S127 M128 M129 T130 C173 R175 Y202 G204 Y205 E206 E208 Y209
Enzymatic activity
Enzyme Commision number
2.1.1.369
: [histone H3]-lysine(27) N-methyltransferase.
External links
PDB
RCSB:5vac
,
PDBe:5vac
,
PDBj:5vac
PDBsum
5vac
PubMed
28383693
UniProt
B9RU15
|ATXR5_RICCO Probable Histone-lysine N-methyltransferase ATXR5 (Gene Name=ATXR5)
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