Structure of PDB 5v9x Chain A Binding Site BS01

Receptor Information
>5v9x Chain A (length=772) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADPLGRFSALTREWFTTAFAAPTPAQADAWSAISEGNNTLVIAPTGSGKT
LAAFLWAIDRLADPQGTQVLYVSPLKALAVDVERNLRTPLTGITRVAERH
GLPAPSITVGVRSGDTPPNQRRAMIANPPDVLITTPESLFLMLTSAARET
LTSVRTVIVDEVHAVAATKRGAHLALSLERLDQLLDTPAQRIGLSATVRP
PEEVARFLSGQAPTTIVCPPAAKTFDLSVQVPVPDMANLDNNSIWPDVEE
RIVDLVEAHNSSIVFANSRRLAERLTSRLNEIHAERSGIEPPLLARAHHG
SVSKEQRAQVEDDLKSGRLRAVVATSSLELGIDMGAVDLVIQVEAPPSVA
SGLQRVGRAGHQVGEISQGVLFPKHRTDLIGCAVTVQRMQTGDIETLRVP
ANPLDVLAQHTVAVAALEPVDADAWFDAVRRSAPFATLPRSAFEATLDLL
SGKAELRPRLVYDRDTGTLTARPGAQRLAVTSGGAIPDRGMFTVYLASET
EELDEEMVYESPGQPARLPFWRGDSVGRPAELGAAVGAFTGELASLDRKA
FDKRCQKMGFAGYATDNLHQLLREQREATGVVPSDTTFVVERFRDELGDW
RVILHSPYGLRVHGPLALAVGRRLRERYGIDEKPTASDDGIIVRLPDSPG
ADLFVFDADEIEPIVTAEVGGSALFASRFRECAARALLLPRRHPGKRSPL
WHQRQRAAQLLDIARKYPDFPIVLEAVRECLQDVYDVPALIELMHKIAQR
RLRIVEVETATPSPFAASLLFG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5v9x Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases.
Resolution2.797 Å
Binding residue
(original residue number in PDB)
L85 K86 R122 G124 R131 T145 S148 L151 S155 R180 S253 I254 W255 N277 S278 R279 H335 G336 T361 S362 K410 H411 Q518 R519 V522 T523 I528 M533 W597 G599 D600 R777 G852
Binding residue
(residue number reindexed from 1)
L75 K76 R112 G114 R121 T135 S138 L141 S145 R170 S243 I244 W245 N267 S268 R269 H299 G300 T325 S326 K374 H375 Q476 R477 V480 T481 I486 M491 W521 G523 D524 R697 G772
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:5v9x, PDBe:5v9x, PDBj:5v9x
PDBsum5v9x
PubMed29165676
UniProtA0QT91

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