Structure of PDB 5v3r Chain A Binding Site BS01

Receptor Information
>5v3r Chain A (length=357) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRR
AAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDK
GSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAK
HYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFL
KATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKEVFPVLAAKHCI
MQANAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKDFS
DKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKF
TDLFEKM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5v3r A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.
Resolution1.906 Å
Binding residue
(original residue number in PDB)		D143 K147 F199 K202 M208 I212 L337
Binding residue
(residue number reindexed from 1)		D142 K146 F198 K201 M207 I211 L336
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0071985 multivesicular body sorting pathway

View graph for
Biological Process
External links
PDB RCSB:5v3r, PDBe:5v3r, PDBj:5v3r
PDBsum5v3r
PubMed30181294
UniProtQ8WUM4|PDC6I_HUMAN Programmed cell death 6-interacting protein (Gene Name=PDCD6IP)

[Back to BioLiP]