Structure of PDB 5v35 Chain A Binding Site BS01

Receptor Information
>5v35 Chain A (length=152) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVEGVKKTILHGGTGELPNFITGSRVIFHFRTMKCDEERTVIDDSRQVGQ
PMHIIIGNMFKLEFWEILLTSMRVHEVAEFWCDTIHTGVYPILSRSLRQM
AQGKDPTEWHVHTCGLANMFAYHTLGYEDLDELQKEPQPLVFVIELLQVD
AP
Ligand information
Ligand IDFAR
InChIInChI=1S/C15H26/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h6,9,12H,7-8,10-11H2,1-5H3/b14-6+,15-12+
InChIKeyJXBSHSBNOVLGHF-BUJBXKITSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CC=C(C)CCC=C(C)CCC=C(C)C
OpenEye OEToolkits 1.5.0C\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
CACTVS 3.341C\C=C(C)\CC\C=C(C)\CCC=C(C)C
ACDLabs 10.04C(=C/C)(\CC/C=C(/CC/C=C(\C)C)C)C
FormulaC15 H26
NameFARNESYL
ChEMBL
DrugBank
ZINC
PDB chain5v35 Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5v35 Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		F37 M59 I61 L100 F149
Binding residue
(residue number reindexed from 1)		F30 M52 I54 L93 F142
Annotation score1
Binding affinityPDBbind-CN: -logKd/Ki=6.96,Kd=110nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:5v35, PDBe:5v35, PDBj:5v35
PDBsum5v35
PubMed28739921
UniProtQ9NZN9|AIPL1_HUMAN Aryl-hydrocarbon-interacting protein-like 1 (Gene Name=AIPL1)

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