Structure of PDB 5v0u Chain A Binding Site BS01

Receptor Information
>5v0u Chain A (length=407) Species: 381518 (Influenza A virus (A/Wilson-Smith/1933(H1N1))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFF
GWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQ
LKWALGEELRSLASWIQNEFNKACELTDSSWIELDEIGEDAAPIEHIASM
RRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRT
KEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYC
VLEVGDMLLRSAIGHVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQ
IESMIEAESSVKEKDMTKEFFENKSPKGVEEGSIGKVCRTLLAKSVFNSL
YASPQLEGFSAESRKLLLIVQALRDNLGGLYEAIEECLINDPWVLLNASW
FNSFLTH
Ligand information
Ligand ID8QG
InChIInChI=1S/C7H5ClN2S/c8-7-2-1-6(11-7)5-3-9-10-4-5/h1-4H,(H,9,10)
InChIKeyFSGXXIOYDLGFFB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385Clc1sc(cc1)c2c[nH]nc2
OpenEye OEToolkits 2.0.6c1cc(sc1c2c[nH]nc2)Cl
ACDLabs 12.01c1nncc1c2ccc(Cl)s2
FormulaC7 H5 Cl N2 S
Name4-(5-chlorothiophen-2-yl)-1H-pyrazole
ChEMBL
DrugBank
ZINCZINC000000480671
PDB chain5v0u Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5v0u Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase
Resolution2.45 Å
Binding residue
(original residue number in PDB)		R312 W317 L342
Binding residue
(residue number reindexed from 1)		R47 W52 L77
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5v0u, PDBe:5v0u, PDBj:5v0u
PDBsum5v0u
PubMed
UniProtP15659|PA_I33A0 Polymerase acidic protein (Gene Name=PA)

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