Structure of PDB 5uw3 Chain A Binding Site BS01

Receptor Information

>5uw3 Chain A (length=693) Species: 39387 (Gypsophila vaccaria)

YPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKLANSVLE
ECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNVFQMQDD
LDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTEWVTIKIL
KTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPNQEARYHFLGTDQS
EDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVYCLDLTKLP
NGLESFAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKKLVRVDLNN
PSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIRDLESGALQ
HRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKNDPTQLKIF
RESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDGSHPCEMHG
YGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEWHKAGFRDK
KQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACINQRPDLFG
CAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKYSPIHNVRR
PWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVLCTSLEDSP
QKNPIIARIQRKAAHYGRATMTQIAEVADRYGFMAKALEAPWI

Ligand information

>5uw3 Chain E (length=6) Species: 39387 (Gypsophila vaccaria)

NASAPV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5uw3 Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.
• Resolution: 1.96 Å
• Binding residue (original residue number in PDB): R81 F95 A102 N104 L132 F492 S493 A494 S495 T700
• Binding residue (residue number reindexed from 1): R70 F84 A91 N93 L121 F462 S463 A464 S465 T670

Enzymatic activity

• Catalytic site (original residue number in PDB): Y481 S562 D653 H695
• Catalytic site (residue number reindexed from 1): Y451 S532 D623 H665
• Enzyme Commision number: 3.4.21.-
  3.4.21.26: prolyl oligopeptidase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding
• GO:0070012 oligopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5uw3, PDBe:5uw3, PDBj:5uw3
• PDBsum: 5uw3
• PubMed: 28584123
• UniProt: R4P353