Structure of PDB 5uoq Chain A Binding Site BS01

Receptor Information
>5uoq Chain A (length=368) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDAELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKI
VLQAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNK
ASGPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYP
TKAPSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLE
FSTPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTY
SPVLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPST
PPASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDH
LGNNRTVSIDNLKPTSHQ
Ligand information
Receptor-Ligand Complex Structure
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PDB5uoq Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.
Resolution2.61 Å
Binding residue
(original residue number in PDB)		I112 L113 R114 P115 E207 F208 S209 T210 Q215 S216 G218 K219 R222 R229 S258 P259 L347 N348 R350 T351 T363
Binding residue
(residue number reindexed from 1)		I105 L106 R107 P108 E200 F201 S202 T203 Q208 S209 G211 K212 R215 R222 S251 P252 L340 N341 R343 T344 T356
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:5uoq, PDBe:5uoq, PDBj:5uoq
PDBsum5uoq
PubMed28285916
UniProtP14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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