Structure of PDB 5un1 Chain A Binding Site BS01

Receptor Information
>5un1 Chain A (length=416) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPDETIPG
RPTVPQCCYGFCVDLLIKLAREMDFTYEVHLVADGKFGTQERVNNSNAAA
WNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIP
RSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFLTLSSAMWFSWRVL
LNSGLGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLRRPEERITG
INDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAE
AIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDS
PWKQEVSLNILKSHENGFMEELDKTWVRYQECDSPATLTFENMAGVFMLV
AGGIVAGIFLIFIEIA
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain5un1 Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5un1 Mechanism of NMDA receptor channel block by MK-801 and memantine.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		F482 P514 L515 T516 R521 S677 S678
Binding residue
(residue number reindexed from 1)		F87 P119 L120 T121 R126 S271 S272
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5un1, PDBe:5un1, PDBj:5un1
PDBsum5un1
PubMed29670280
UniProtA0A1L8F5J9|NMDZ1_XENLA Glutamate receptor ionotropic, NMDA 1 (Gene Name=grin1)

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