Structure of PDB 5ulx Chain A Binding Site BS01

Receptor Information
>5ulx Chain A (length=373) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKDVMTPMVDI
LMKLFRNMVNVLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB5ulx Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota.
Resolution1.96 Å
Binding residue
(original residue number in PDB)		L123 E127 K207 G241 G243 Y244 K245 T246 E358 S359
Binding residue
(residue number reindexed from 1)		L98 E102 K182 G216 G218 Y219 K220 T221 E328 S329
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5ulx, PDBe:5ulx, PDBj:5ulx
PDBsum5ulx
PubMed28272441
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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