Structure of PDB 5ulw Chain A Binding Site BS01

Receptor Information
>5ulw Chain A (length=373) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKDVMTPMVDI
LMKLFRNMVNVLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB5ulw Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota.
Resolution2.617 Å
Binding residue
(original residue number in PDB)		E127 K207 I242 G243 K245 T246 E358 S359
Binding residue
(residue number reindexed from 1)		E102 K182 I217 G218 K220 T221 E328 S329
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5ulw, PDBe:5ulw, PDBj:5ulw
PDBsum5ulw
PubMed28272441
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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