Structure of PDB 5u8c Chain A Binding Site BS01

Receptor Information

>5u8c Chain A (length=284) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDRH
TVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWN
GMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKGTRIT
GINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAA
EAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKD
SPWKQNVSLSILKSHENGFMEDLDKTWVRYQECD

Ligand information

Ligand ID

GLY

InChI

InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChIKey

DHMQDGOQFOQNFH-UHFFFAOYSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	C(C(=O)O)N
CACTVS 3.341	NCC(O)=O
ACDLabs 10.04	O=C(O)CN

Formula

C2 H5 N O2

Name

GLYCINE

PDB chain

5u8c Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5u8c Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077.
Resolution	1.598 Å
Binding residue (original residue number in PDB)	F92 P124 L125 T126 R131 S179 S180 D224
Binding residue (residue number reindexed from 1)	F85 P117 L118 T119 R124 S172 S173 D217
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0015276	ligand-gated monoatomic ion channel activity

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:5u8c, PDBe:5u8c, PDBj:5u8c
PDBsum	5u8c
PubMed	28468946
UniProt	P35439\|NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (Gene Name=Grin1)

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