Structure of PDB 5u62 Chain A Binding Site BS01

Receptor Information
>5u62 Chain A (length=349) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHS
QGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPI
TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAI
FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESY
DYRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPG
KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG
KLYVWDLEVCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL
Ligand information
>5u62 Chain C (length=26) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SSNRQKILERTEILNQEWKQRRIQPV
Receptor-Ligand Complex Structure
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PDB5u62 Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		W103 H104 S105 D109 Y154 S159 H160 P161 P177 I178 R201 L246 L315 G316 D317 L318 F372 W373 Q374 R420
Binding residue
(residue number reindexed from 1)		W25 H26 S27 D31 Y76 S81 H82 P83 P99 I100 R123 L168 L231 G232 D233 L234 F288 W289 Q290 R329
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:5u62, PDBe:5u62, PDBj:5u62
PDBsum5u62
PubMed27992714
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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