Structure of PDB 5u5t Chain A Binding Site BS01
Receptor Information
>5u5t Chain A (length=348) Species:
9606
(Homo sapiens) [
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KYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHS
QGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPI
TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAI
FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESY
DYFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKM
EDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKL
YVWDLEVECTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL
Ligand information
>5u5t Chain C (length=26) Species:
9606
(Homo sapiens) [
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SSNRQKILERTEILNQEWKQRRIQPV
Receptor-Ligand Complex Structure
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PDB
5u5t
Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
Resolution
1.6 Å
Binding residue
(original residue number in PDB)
W103 H104 S105 E107 D109 Y154 S159 P161 P177 R201 L246 L247 L315 G316 D317 L318 F372 W373 Q374 R420
Binding residue
(residue number reindexed from 1)
W25 H26 S27 E29 D31 Y76 S81 P83 P99 R123 L168 L169 L229 G230 D231 L232 F286 W287 Q288 R328
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5u5t
,
PDBe:5u5t
,
PDBj:5u5t
PDBsum
5u5t
PubMed
27992714
UniProt
O75530
|EED_HUMAN Polycomb protein EED (Gene Name=EED)
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