Structure of PDB 5txk Chain A Binding Site BS01

Receptor Information
>5txk Chain A (length=317) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKSDTGKIGLINLGNTSYVNSILQALFMASDFRHCVLRLTENNSQPLMTK
LQWLFGFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLH
EEEKTGTRICQKLKQSSSSSTSVEKMFGGKIVTRICCLCCLNVSSREEAF
TDLSLAFPPPSRSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEKVVEL
SQGPCYLILTLLRFSFDLRTMRRRKILDDVSIPLLLRLPLAGGRGQAYDL
CSVVVHSGVSSESGHYYCYAREGAARENQWYLFNDTRVSFSSFESVSNVT
SFFPKDTAYVLFYRQRP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5txk Chain A Residue 1006 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5txk Expansion of DUB functionality generated by alternative isoforms - USP35, a case study.
Resolution1.84 Å
Binding residue
(original residue number in PDB)		C580 C583 C782 C785
Binding residue
(residue number reindexed from 1)		C137 C140 C185 C188
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5txk, PDBe:5txk, PDBj:5txk
PDBsum5txk
PubMed29685892
UniProtQ9P2H5|UBP35_HUMAN Ubiquitin carboxyl-terminal hydrolase 35 (Gene Name=USP35)

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