Structure of PDB 5tua Chain A Binding Site BS01

Receptor Information
>5tua Chain A (length=627) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKAAALVDLAEDGIGLPVEILDFGESARYYFIFTRLDLIWSLNYFALLFL
NFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEVITLAILLVH
TFFPISYEGSRIFWTSRLNLVKVACVVILFVDVLVDFLYFRIAPYVRVII
FILSIRELRDTLVLLSGMLGTYLNILALWMLFLLFASWIAFVMFEDTQQG
LTVFTSYGATLYQMFILFTTANNPDVWIPAYKSSRWSSVFFVLYVLIGVY
FVTNLILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNGEIDK
NQCIKLFEQLTNYRTLPKISKEEFGLIFDELDDTRDFKINKDEFADLCQA
IALRFQKEEVPQIYHSALSQQLRAFVRSPNFGYAISFILIINFIAVVVET
TLDIEESSAQKPWQVAEFVFGWIYVLEMALKIYTYGFENYWREGANRFDF
LVTWVIVIGETATFITPFSNGEWIRYLLLARMLRLIRLLMNVQRYRAFIA
TFITLIPSLMPYLGTIFCVLCIYCSIGVQVFGGLGNKKLFETELAEDDYL
LFNFNDYPNGMVTLFNLLVVNNWQVWMESYKDLTGTWWSITYFVSFYVIT
ILLLLNLVVAFVLEAFFTELDLEEEEK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5tua Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5tua Tuning the ion selectivity of two-pore channels.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		D335 D337 N339 E341
Binding residue
(residue number reindexed from 1)		D291 D293 N295 E297
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0009845 seed germination
GO:0010119 regulation of stomatal movement
GO:0019722 calcium-mediated signaling
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0080141 regulation of jasmonic acid biosynthetic process
Cellular Component
GO:0000325 plant-type vacuole
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5tua, PDBe:5tua, PDBj:5tua
PDBsum5tua
PubMed28096396
UniProtQ94KI8|TPC1_ARATH Two pore calcium channel protein 1 (Gene Name=TPC1)

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