Structure of PDB 5tsq Chain A Binding Site BS01

Receptor Information

>5tsq Chain A (length=312) Species: 1448350 (Leishmania braziliensis braziliensis)

PRKIILDCDPGIDDAVAILLAYGNPEIELLAITTVVGNQTLEKVTRNAQL
VADVAGIVGVPIAAGCCKPLVRKVRTAPQIHGETGLGTVSYPSEFKTKLD
KRHAVHLIIELIMSHEPKSITLVPTGGLTNIAMAARLEPRIVERVKEVVL
MGGSCCIGNASPVAEFNIFVDPEAAHIVFNESWDVTMVGLDLTSQALATP
EVLQRVKEVRTKPADFILKILEFYTKVYETQRNTYAKVHDPCAVAYVIDP
TVMTTNRVPVNIELNGELTAGMTVTDFRYPRPEQCHTQVASKLDFSKYWD
LVIDALQRIGDP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5tsq Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5tsq Crystal structure of IUnH from Leishmania braziliensis in complex with D-Ribose
• Resolution: 1.53 Å
• Binding residue (original residue number in PDB): D10 D15 T126 D241
• Binding residue (residue number reindexed from 1): D9 D14 T125 D240
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D10 D15 N39 V75 T126 F167 N168 H240 D241
• Catalytic site (residue number reindexed from 1): D9 D14 N38 V74 T125 F166 N167 H239 D240
• Enzyme Commision number: 3.2.2.1: purine nucleosidase.

Gene Ontology

Molecular Function

• GO:0008477 purine nucleosidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
• GO:0045437 uridine nucleosidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006139 nucleobase-containing compound metabolic process
• GO:0006152 purine nucleoside catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5tsq, PDBe:5tsq, PDBj:5tsq
• PDBsum: 5tsq
• UniProt: A4H9Q9