Structure of PDB 5tsn Chain A Binding Site BS01

Receptor Information
>5tsn Chain A (length=500) Species: 11983 (Norwalk virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKGTYCGAPILGPGSAPKLSTKTKFWRSSTAPLPPGTYEPAYLGGKDPRV
KGGPSLQQVMRDQLKPFTEPRGKPPKPSVLEAAKKTIINVLEQTIDPPDK
WSFAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLADQASKANLMFEE
GKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGLM
DELKTHCVTLPIRVGMNMNEDGPIIFERHSRYRYHYDADYSRWDSTQQRA
VLAAALEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFTISINEGLPSGVP
CTSQWNSIAHWLLTLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKL
DPEKLTAKLKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWF
GKLEQSSILRQMYWTRGPNHEDPSETMIPHSQRPIQLMSLLGEAALHGPA
FYSKISKLVIAELKEGGFYVPRQEPMFRWMRFSDLSTWEGDRNLAPSFVN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5tsn Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		T116 K166 R182 L184 D247 S300 G301 S306 Y341 D343 D344 L391 R392 R393 S410 R413 Q414 R419 Q435 Q439
Binding residue
(residue number reindexed from 1)		T113 K163 R179 L181 D244 S297 G298 S303 Y338 D340 D341 L388 R389 R390 S407 R410 Q411 R416 Q432 Q436
Enzymatic activity
Enzyme Commision number 3.4.22.66: calicivirin.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5tsn, PDBe:5tsn, PDBj:5tsn
PDBsum5tsn
PubMed28383118
UniProtQ70ET3

[Back to BioLiP]