Structure of PDB 5trb Chain A Binding Site BS01

Receptor Information
>5trb Chain A (length=69) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRK
CPKCNAAFGANDFHRIYIG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5trb Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5trb Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C922 C925 C942 C945
Binding residue
(residue number reindexed from 1)		C16 C19 C36 C39
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5trb, PDBe:5trb, PDBj:5trb
PDBsum5trb
PubMed27569044
UniProtQ5VTR2|BRE1A_HUMAN E3 ubiquitin-protein ligase BRE1A (Gene Name=RNF20)

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