Structure of PDB 5tqc Chain A Binding Site BS01

Receptor Information
>5tqc Chain A (length=840) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFV
LTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSS
PLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQ
KICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFII
SRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPH
MHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPV
LVNGMKYSDIDIILLKGDTISDWNLRKCSAAALDVLANVYRDELLPHILP
LLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDK
KALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAA
CSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLAD
SVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSG
FLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSG
LAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQ
HVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMV
LHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTS
LRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLR
DMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
Ligand information
>5tqc Chain B (length=7) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MLRLNPY
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5tqc Molecular basis for protection of ribosomal protein L4 from cellular degradation.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K377 A380 D384 L419 A423 W460 T506 E509 D543
Binding residue
(residue number reindexed from 1)		K327 A330 D334 L369 A373 W410 T456 E459 D493
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0031267 small GTPase binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport

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Molecular Function
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Biological Process
External links
PDB RCSB:5tqc, PDBe:5tqc, PDBj:5tqc
PDBsum5tqc
PubMed28148929
UniProtQ92973|TNPO1_HUMAN Transportin-1 (Gene Name=TNPO1)

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