Structure of PDB 5tkm Chain A Binding Site BS01

Receptor Information
>5tkm Chain A (length=184) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPMERMDRDTFYDNFENEPILSGRSYTWLCYEVKIKRGRSNLLWDTGVFR
GQVYFKPQYHAEMCFLSWFCGNQLPADKCFQITWFVSWTPCPDCVAKLAE
FLSEHPNVTLTISAARLYYYSERDYRRALCRLSQAGARVKIMDYEEFAYC
WENFVDNEGQQFMPWYKFDENYAFLHRTLKEILR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5tkm Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5tkm Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		H66 C97 C100
Binding residue
(residue number reindexed from 1)		H60 C91 C94
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5tkm, PDBe:5tkm, PDBj:5tkm
PDBsum5tkm
PubMed28575276
UniProtQ9UH17|ABC3B_HUMAN DNA dC->dU-editing enzyme APOBEC-3B (Gene Name=APOBEC3B)

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