Structure of PDB 5tfl Chain A Binding Site BS01

Receptor Information
>5tfl Chain A (length=202) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPTFSKPAYFVSVLENIMAGATVLFLNATDSIIYSLEGSSQFRINARSGE
ITTTSLLDRETKSEYILIVRAVDNQKTGIATVNVTLLDINDNHPTWKDAP
YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIHPPNKFYSLNSTTGK
IRTTHVMLDRENPDPVEAELMRKIIVSVTDCGRPPLKATSSATVFVNLLD
LN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5tfl Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5tfl Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Resolution3.56 Å
Binding residue
(original residue number in PDB)		E659 E714 D747 I748 D750 D783
Binding residue
(residue number reindexed from 1)		E15 E60 D88 I89 D91 D124
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5tfl, PDBe:5tfl, PDBj:5tfl
PDBsum5tfl
PubMed30033219
UniProtQ99PF4|CAD23_MOUSE Cadherin-23 (Gene Name=Cdh23)

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