Structure of PDB 5teg Chain A Binding Site BS01

Receptor Information
>5teg Chain A (length=160) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFV
VEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNR
LGRLINHSKSGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKA
SIEAHPWLKH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5teg Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.
Resolution1.3 Å
Binding residue
(original residue number in PDB)		E259 Y262 C270 M272 Y273 Y274 T307 Y334 D335 Y336 G337 D338 A342 S343 H347
Binding residue
(residue number reindexed from 1)		E67 Y70 C78 M80 Y81 Y82 T115 Y142 D143 Y144 G145 D146 A150 S151 H155
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5teg, PDBe:5teg, PDBj:5teg
PDBsum5teg
PubMed27994746
UniProtQ9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)

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