Structure of PDB 5t4m Chain A Binding Site BS01

Receptor Information

>5t4m Chain A (length=347) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR
NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF
DLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVG
ATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITR
YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE
ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT
TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

5t4m Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5t4m A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15.
Resolution	2.24 Å
Binding residue (original residue number in PDB)	E367 N369 D411
Binding residue (residue number reindexed from 1)	E127 N129 D171
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:5t4m, PDBe:5t4m, PDBj:5t4m
PDBsum	5t4m
PubMed	28238533
UniProt	Q96QU1\|PCD15_HUMAN Protocadherin-15 (Gene Name=PCDH15)

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