Structure of PDB 5t0m Chain A Binding Site BS01

Receptor Information
>5t0m Chain A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITH
LQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGE
LISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRV
FMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEK
CKHSAEAIAL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t0m A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.
Resolution1.896 Å
Binding residue
(original residue number in PDB)		Y1067 D1074 A1077 D1078 D1083 L1086 F1087 D1088 Y1154 R1157 F1158 I1161
Binding residue
(residue number reindexed from 1)		Y147 D154 A157 D158 D163 L166 F167 D168 Y230 R233 F234 I237
Enzymatic activity
Catalytic site (original residue number in PDB) Y1067 Y1154
Catalytic site (residue number reindexed from 1) Y147 Y230
Enzyme Commision number 2.1.1.-
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0008270 zinc ion binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:5t0m, PDBe:5t0m, PDBj:5t0m
PDBsum5t0m
PubMed27648579
UniProtQ96KQ7|EHMT2_HUMAN Histone-lysine N-methyltransferase EHMT2 (Gene Name=EHMT2)

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