Structure of PDB 5t04 Chain A Binding Site BS01

Receptor Information

>5t04 Chain A (length=458) Species: 10116,10665

TSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARS
TVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRD
ACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALL
AIPMLFTMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPM
LVISILNTVIANKLTVMVNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLL
TKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAK
LKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLNNKRWDEAAVNL
AKSRWYNQTPNRAKRVITTFRTGTWDAYGSGSPGRVQALRHGVLVLRAVV
IAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALAYASSAI
NPILYNLV

Ligand information

>5t04 Chain B (length=6) Species: 10116 (Rattus norvegicus)

RRPYIL

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5t04 Structure and dynamics of a constitutively active neurotensin receptor.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): D54 L55 H132 Y146 T226 T231 R327 F331 D336 W339 F344 Y347
• Binding residue (residue number reindexed from 1): D12 L13 H82 Y96 T176 T181 R413 F417 D422 W425 F430 Y433

Enzymatic activity

• Catalytic site (original residue number in PDB): E1011 D1020
• Catalytic site (residue number reindexed from 1): E228 D237
• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0004930 G protein-coupled receptor activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0009253 peptidoglycan catabolic process
• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0044659 viral release from host cell by cytolysis

Cellular Component

• GO:0016020 membrane
• GO:0030430 host cell cytoplasm

External links

• PDB: RCSB:5t04, PDBe:5t04, PDBj:5t04
• PDBsum: 5t04
• PubMed: 27924846
• UniProt: P00720|ENLYS_BPT4 Endolysin (Gene Name=E);
  P20789|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)