Structure of PDB 5r65 Chain A Binding Site BS01

Receptor Information
>5r65 Chain A (length=197) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMLERTINLYPLTNYTFGTKEPLYEKDSSVAARFQRMREEFDKIGMRRTV
EGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRLMTEILG
RQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQ
EKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN
Ligand information
Ligand IDK0Y
InChIInChI=1S/C8H10N2O4/c1-5-3-6(10-14-5)8(12)9-4-7(11)13-2/h3H,4H2,1-2H3,(H,9,12)
InChIKeyFPAQMEYCJIMDCC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385COC(=O)CNC(=O)c1cc(C)on1
OpenEye OEToolkits 2.0.6Cc1cc(no1)C(=O)NCC(=O)OC
ACDLabs 12.01n1c(C(NCC(OC)=O)=O)cc(C)o1
FormulaC8 H10 N2 O4
Namemethyl N-(5-methyl-1,2-oxazole-3-carbonyl)glycinate
ChEMBL
DrugBank
ZINCZINC000000128548
PDB chain5r65 Chain A Residue 305 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5r65 PanDDA analysis group deposition
Resolution2.28 Å
Binding residue
(original residue number in PDB)		E81 L106 G108 I128 Y191
Binding residue
(residue number reindexed from 1)		E51 L76 G78 I98 Y161
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005849 mRNA cleavage factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5r65, PDBe:5r65, PDBj:5r65
PDBsum5r65
PubMed
UniProtO43809|CPSF5_HUMAN Cleavage and polyadenylation specificity factor subunit 5 (Gene Name=NUDT21)

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