Structure of PDB 5qsk Chain A Binding Site BS01

Receptor Information

>5qsk Chain A (length=171) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSF
LLDFVAADNHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAP
VSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGDPQRMITSHCFPET
QFIAVTAYQNEEITALKIKYN

Ligand information

Ligand ID

O1J

InChI

InChI=1S/C9H10O3/c10-9(11)7-12-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,11)

InChIKey

GRZHHTYDZVRPIC-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.385	OC(=O)COCc1ccccc1
OpenEye OEToolkits 2.0.6	c1ccc(cc1)COCC(=O)O
ACDLabs 12.01	c1ccccc1COCC(=O)O

Formula

C9 H10 O3

Name

(benzyloxy)acetic acid

PDB chain

5qsk Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5qsk PanDDA analysis group deposition
Resolution	1.55 Å
Binding residue (original residue number in PDB)	L82 Y88 I172 R174 M181 T183
Binding residue (residue number reindexed from 1)	L42 Y48 I132 R134 M141 T143
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0045893	positive regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:5qsk, PDBe:5qsk, PDBj:5qsk
PDBsum	5qsk
PubMed
UniProt	O15178\|TBXT_HUMAN T-box transcription factor T (Gene Name=TBXT)

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