Structure of PDB 5qqo Chain A Binding Site BS01
Receptor Information
>5qqo Chain A (length=238) Species:
9606
(Homo sapiens) [
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IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE
SPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLE
TTVGYGDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKI
PLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVW
HLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
Ligand information
>5qqo Chain H (length=7) Species:
9606
(Homo sapiens) [
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CTTKIKP
Receptor-Ligand Complex Structure
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PDB
5qqo
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
I47 N49 C122 L123 L239 Q243
Binding residue
(residue number reindexed from 1)
I34 N36 C113 L114 L232 Q236
Enzymatic activity
Catalytic site (original residue number in PDB)
H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)
H44 D93 K185 G186 D187 S188 G189
Enzyme Commision number
3.4.21.27
: coagulation factor XIa.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
Biological Process
GO:0006508
proteolysis
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Molecular Function
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Biological Process
External links
PDB
RCSB:5qqo
,
PDBe:5qqo
,
PDBj:5qqo
PDBsum
5qqo
PubMed
31445854
UniProt
P03951
|FA11_HUMAN Coagulation factor XI (Gene Name=F11)
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