Structure of PDB 5qop Chain A Binding Site BS01

Receptor Information

>5qop Chain A (length=149) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREV
FEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIR
NIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFG

Ligand information

Ligand ID

LDD

InChI

InChI=1S/C14H19NO2/c1-17-13-8-6-12(7-9-13)14(16)15-10-4-2-3-5-11-15/h6-9H,2-5,10-11H2,1H3

InChIKey

OOKCGNCOULVMQS-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 12.01	N1(CCCCCC1)C(c2ccc(cc2)OC)=O
CACTVS 3.385 OpenEye OEToolkits 2.0.6	COc1ccc(cc1)C(=O)N2CCCCCC2

Formula

C14 H19 N O2

Name

(azepan-1-yl)(4-methoxyphenyl)methanone

PDB chain

5qop Chain A Residue 306 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5qop PanDDA analysis group deposition
Resolution	1.86 Å
Binding residue (original residue number in PDB)	K121 K128 G129
Binding residue (residue number reindexed from 1)	K26 K33 G34
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.6.1.62: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.

Gene Ontology

	Molecular Function
GO:0016787	hydrolase activity
GO:0140933	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity

	Biological Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function

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Biological Process

External links

PDB	RCSB:5qop, PDBe:5qop, PDBj:5qop
PDBsum	5qop
PubMed
UniProt	Q8IU60\|DCP2_HUMAN m7GpppN-mRNA hydrolase (Gene Name=DCP2)

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