Structure of PDB 5oy3 Chain A Binding Site BS01
Receptor Information
>5oy3 Chain A (length=450) Species:
9606
(Homo sapiens) [
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ESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCT
DPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDEN
WDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESHIIKFGTNIDLSDAK
RWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTP
GHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWW
PILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPL
TAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKF
CLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFV
TSEGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLAPA
Ligand information
>5oy3 Chain B (length=17) Species:
9606
(Homo sapiens) [
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RKQLMTKAARKSAPATG
Receptor-Ligand Complex Structure
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PDB
5oy3
Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity.
Resolution
2.136 Å
Binding residue
(original residue number in PDB)
E1244 R1246 S1270 S1271 R1272 N1331 D1333 L1371 G1372 Q1377 G1435 N1484 Q1564 V1567 Y1573 D1579 T1597 Y1598
Binding residue
(residue number reindexed from 1)
E88 R90 S114 S115 R116 N143 D145 L183 G184 Q189 G247 N296 Q376 V379 Y385 D391 T408 Y409
Enzymatic activity
Enzyme Commision number
1.14.11.68
: [histone H3]-trimethyl-L-lysine(27) demethylase.
External links
PDB
RCSB:5oy3
,
PDBe:5oy3
,
PDBj:5oy3
PDBsum
5oy3
PubMed
29220567
UniProt
O15054
|KDM6B_HUMAN Lysine-specific demethylase 6B (Gene Name=KDM6B)
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