Structure of PDB 5oxk Chain A Binding Site BS01

Receptor Information

>5oxk Chain A (length=437) Species: 264199 (Streptococcus thermophilus LMG 18311)

KTFFGQPLGLSTLFMTEMWERFSYYGMRAILLYYMWFLISTGDLHITRAT
AASIMAIYASMVYLSGTIGGFVADRIIGARPAVFWGGVLIMLGHIVLALP
FGASALFGSIILIIIGTGFLKPNVSTLVGTLYDEHDRRRDAGFSIFVFGI
NLGAFIAPLIVGAAQEAAGYHVAFSLAAIGMFIGLLVYYFGGKKTLDPHY
LRPTDPLAPEEVKPLLVKVSLAVAGFIAIIVVMNLVGWNSLPAYINLLTI
VAIAIPVFYFAWMIVVSYIPLFIAAVLFWAIEEQGSVVLATFAAERVDSS
WFPVSWFQSLNPLFIMLYTPFFAWLWTAWPSSPTKFAVGLMFAGLSFLLM
AIPGALYGTSGKVSPLWLVGSWALVILGEMLISPNSQMMSMWFLSSSVGS
ALNAQLVTLYNAKSEVAYFSYFGLGSVVLGIVLVFLS

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 5oxk Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5oxk Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter.
• Resolution: 2.38 Å
• Binding residue (original residue number in PDB): D48 G107 A108 S109
• Binding residue (residue number reindexed from 1): D43 G102 A103 S104
• Annotation score: 3

Gene Ontology

Molecular Function

• GO:0022857 transmembrane transporter activity
• GO:0042802 identical protein binding
• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0006857 oligopeptide transport
• GO:0015833 peptide transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5oxk, PDBe:5oxk, PDBj:5oxk
• PDBsum: 5oxk
• PubMed: 29429879
• UniProt: Q5M4H8