Structure of PDB 5owu Chain A Binding Site BS01

Receptor Information
>5owu Chain A (length=860) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLID
ENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNA
LTALVSIEPRIANAAAQLIAAIADIELPHGAWPELMKIMVDNTGAEQPEN
VKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQSTETSKAVRLA
ALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCK
IMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDI
AYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDEDDDWNVSMSA
GACLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPD
KVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQH
LPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVD
GLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLG
QTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGL
FFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQV
DSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPA
VLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVL
EAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRA
AVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLFSQATKDTARWA
REQQKRQLSL
Ligand information
>5owu Chain B (length=29) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NSSFTPSTVPNINFSTNALRPSDIFGANA
Receptor-Ligand Complex Structure
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PDB5owu Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		N178 L181 I182 V185 E221 Y224 M226 Q227 C230 E231 K260 Y262 E264 Q265 A266 Y268 L270 F317
Binding residue
(residue number reindexed from 1)		N178 L181 I182 V185 E221 Y224 M226 Q227 C230 E231 K260 Y262 E264 Q265 A266 Y268 L270 F317
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0031267 small GTPase binding
GO:0044877 protein-containing complex binding
GO:0061608 nuclear import signal receptor activity
GO:0061676 importin-alpha family protein binding
GO:0097718 disordered domain specific binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0006612 protein targeting to membrane
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0046822 regulation of nucleocytoplasmic transport
GO:0051028 mRNA transport
GO:0051170 import into nucleus
GO:0051292 nuclear pore complex assembly
GO:0060188 regulation of protein desumoylation
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0042564 NLS-dependent protein nuclear import complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5owu, PDBe:5owu, PDBj:5owu
PDBsum5owu
PubMed15878174
UniProtQ06142|IMB1_YEAST Importin subunit beta-1 (Gene Name=KAP95)

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