Structure of PDB 5ol0 Chain A Binding Site BS01
Receptor Information
>5ol0 Chain A (length=283) Species:
5671
(Leishmania infantum) [
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APHQEHVLGEPTLEGLAHYIREKNVRRILVLVGAGASVAAGIPDFRSPDT
GIYANLGKYNLEDPTDAFSLTLLREKPEIFYSIARELNLWPGHFQPTAVH
HFIRLLQDEGRLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECH
TPFSIEQNYLEAMSGTVSRCSTCGGIVKPNVVFFGENLPDAFFDALHHDA
PIAELVIIIGTSMQVHPFALLPCVVPKSVPRVVMNRERVGGLLFRFDVCR
DVLFRGDCQENVVTLAEYLGLSEALAKRMRLSD
Ligand information
>5ol0 Chain C (length=8) Species:
9606
(Homo sapiens) [
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RHKKLMFK
Receptor-Ligand Complex Structure
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PDB
5ol0
The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design.
Resolution
1.99 Å
Binding residue
(original residue number in PDB)
H144 V188 F189 F190 G191 E192 N193 L194 F199 V221 H222 P223
Binding residue
(residue number reindexed from 1)
H138 V182 F183 F184 G185 E186 N187 L188 F193 V215 H216 P217
Enzymatic activity
Catalytic site (original residue number in PDB)
P49 D50 F51 R52 N125 D127 H144
Catalytic site (residue number reindexed from 1)
P43 D44 F45 R46 N119 D121 H138
Enzyme Commision number
2.3.1.286
: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136
NAD-dependent histone deacetylase activity
GO:0051287
NAD binding
GO:0070403
NAD+ binding
View graph for
Molecular Function
External links
PDB
RCSB:5ol0
,
PDBe:5ol0
,
PDBj:5ol0
PDBsum
5ol0
PubMed
29543820
UniProt
A0A6L0XH39
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