Structure of PDB 5ohp Chain A Binding Site BS01

Receptor Information

>5ohp Chain A (length=315) Species: 9606 (Homo sapiens)

KGLVPGLVNLGNTAFMNSLLQGLSACPAFIRWLEEFTSQYSHQYLSLTLL
HLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITS
SLEDERDGSGSHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSI
PAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEHQRTTFVKQLKLGK
LPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLSMDEYKYHSNASTYLFR
LMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQ
EVLSSSAYLLFYERV

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5ohp Chain A Residue 800

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ohp Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): C234 C237 C284 C287
• Binding residue (residue number reindexed from 1): C129 C132 C179 C182
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): N72 A77 H452 S477
• Catalytic site (residue number reindexed from 1): N9 A14 H265 S290
• Enzyme Commision number: 3.4.19.12: ubiquitinyl hydrolase 1.

Gene Ontology

Molecular Function

• GO:0004843 cysteine-type deubiquitinase activity

Biological Process

• GO:0016579 protein deubiquitination

External links

• PDB: RCSB:5ohp, PDBe:5ohp, PDBj:5ohp
• PDBsum: 5ohp
• PubMed: 28945249
• UniProt: Q70CQ3|UBP30_HUMAN Ubiquitin carboxyl-terminal hydrolase 30 (Gene Name=USP30)