Structure of PDB 5ofn Chain A Binding Site BS01

Receptor Information

>5ofn Chain A (length=319) Species: 273057 (Saccharolobus solfataricus P2)

TNLIKSFFRNYYLNAELELPKDMELREFALQPFGSDTYVRHLSFSSSEEL
RDYLVNRNLPLHLFYSSARYQLPSARNMEEKAWMGSDLLFDIDADHLCKL
RSIRFCPVCGNAVVSEKCERDNVETLEYVEMTSECIKRGLEQTRNLVEIL
EDDFGLKPKVYFSGNRGFHVQVDCYGNCALLDSDERKEIAEYVMGIGVPG
YPGGSENAPGWVGRKNRGINGVTIDEQVTIDVKRLIRIPNSLHGKSGLIV
KRVPNLDDFEFNETLSPFTGYTIFLPYITIETEVLGSIIKLNRGIPIKIK
SSIGIYLHLRNLGEVKAYV

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5ofn Chain A Residue 1000

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ofn Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster.
• Resolution: 3.005 Å
• Binding residue (original residue number in PDB): C116 C119 C128 D131
• Binding residue (residue number reindexed from 1): C106 C109 C118 D121
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.-

Gene Ontology

Molecular Function

• GO:0003896 DNA primase activity
• GO:0005515 protein binding
• GO:0016779 nucleotidyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006260 DNA replication
• GO:0006269 DNA replication, synthesis of primer

Cellular Component

• GO:0000428 DNA-directed RNA polymerase complex
• GO:1990077 primosome complex

External links

• PDB: RCSB:5ofn, PDBe:5ofn, PDBj:5ofn
• PDBsum: 5ofn
• PubMed: 29167441
• UniProt: Q97Z83|PRIS_SACS2 DNA primase small subunit PriS (Gene Name=priS)